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What Is Profhilo Treatment? Everything You Need to Know

Published 30th June 2025
min read

Expert Reviewed By

Looking for a natural way to refresh your skin and combat the early signs of ageing? Profhilo treatment might just be your new best friend. Profhilo is an injectable that works the surface to deliver hydration, improve skin firmness, and overall radiance. In this article, you’ll learn everything you need to know about Profhilo treatment and its advanced sister, Profhilo Structura. We will cover:

What is Profhilo Treatment?

Profhilo is a popular injectable moisturising treatment made with pure hyaluronic acid, commonly used to address early signs of ageing. Unlike traditional dermal fillers, it doesn’t add volume but instead stimulates collagen and elastin production – a process known as bio-remodelling. This helps to skin laxity and a more uniform, tightened appearance by activating fibroblasts within the skin.

is also known as a skin that works by deeply hydrating dull skin, improving skin tone and texture and giving you that radiant, healthy glow. Because it’s placed and spreads easily under the skin, it delivers intense hydration across a wider area.

One of the major benefits of Profhilo treatment is its versatility. It can be used on the: 

These are all common areas of concern as we age. 

How Long Does Profhilio Take to Work?

Profhilo takes around four to six weeks to start showing results. The slow release of hyaluronic acid activates fibroblasts, which boosts collagen production gradually and naturally. This particular filler into the skin very well, so the skin becomes firmer, more radiant and better hydrated over time. 

You’ll notice your skin tighter and looking healthier after the second treatment, with results lasting up to six months depending on your lifestyle, skin condition and sun exposure.

For the best glow-up, a course of two to three Profhilo treatments is recommended, spaced three to five weeks apart. Each treatment helps build on the last, so your skin keeps getting firmer and more radiant over time.

Is Profhilo Safe?

Yes, Profhilo is considered safe when administered by a and experienced practitioner. It uses non-crosslinked hyaluronic acid, which is highly with your body’s natural hyaluronic acid, reducing the risk of adverse . 

Additionally, Profhilo’s safety and effectiveness have been recognised within the industry due to its unique approach to skin hydration and remodelling. It won the 2022 for "Injectable Product of the Year" and was for "Product Innovation of the Year". 

What is Profhilo Structura?

So, what is and how is it different from the original Profhilo treatment? Profhilo Structura is a more advanced version designed for skin tightening and mild lifting. It targets deeper layers, making it ideal for and defining facial contours while still improving hydration.  

It helps regenerate, rehydrate and repair the superficial fat pad under the skin. This provides natural support and subtle contouring. This layer plays an important role in facial structure and support. As we age, we naturally lose volume in this fat layer, which contributes to sagging and hollowing, especially in areas like the cheeks and around the ears.

Structura targets this layer when cells are active, further stimulating collagen and elastin production for a firming, lifting effect. Profhilo Structura can lift the lateral cheeks and soften hollows in front of the ears, restoring volume and structure gently and effectively.

Profhilo Structura vs Profhilo

Profhilo Structura is not a replacement for Profhilo but is designed to it. The key difference lies in the depth of application.

While Profhilo is injected into the skin, Structura is placed one layer deeper – into the superficial fat just beneath the skin. Profhilo has a higher grade of hyaluronic acid, making it denser. This makes it perfect for lifting and tightening sagging skin, as well as adding natural-looking volume to areas that may appear sunken.

If your skin is looking a little dull, dry or tired, Profhilo can give it a much-needed boost:

If you’re noticing a bit more or volume loss around your cheeks, jawline or temples, Profhilo Structura might be your go-to:

Profhilo Structura at Thames Skin Clinic

Profhilo Structura was launched in the UK on 4th June last year. , who is behind , was the UK’s biggest user during the national study. 

This allowed her to present practical knowledge and clinical insights about Profhilo Structura at the Kings Fund launch event. 

She gained extensive practical experience with the treatment after personally travelling to Milan to train with , the makers of Profhilo and Profhilo Structura. This is why we are uniquely positioned to offer expert Profhilo Structura in our Twickenham-based clinic with confidence and precision.

Since then, we have used Profhilo and Profhilo Structura treatments to create bespoke skin restoration programmes, including:

Patients at our award-winning clinic benefit from Dr Anna’s deep expertise and understanding of Profhilo Structura. today to achieve natural lifting and improved facial structure safely and effectively.

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Baylis Mews,

Twickenham TW1 3HQ

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